Recent innovation in vaccine development spotlights the demand for robust technology to measure cytokines, immunoglobulins, and more
The Luminex team was pleased to attend this year’s World Vaccine Congress, which took place in April in Washington, DC. With so much innovation in vaccine development and commercialization occurring globally, it was exciting to learn about the latest advancements from some of the field’s leaders.
The Growing Need for Reliable Immune Profiling Technologies in Vaccine Development
The event’s highlights spanned the vaccine development spectrum, from basic research to manufacturing. We heard from government and regulatory experts, pharmaceutical executives, and scientists from leading vaccine research institutions. Along with thousands of attendees, we learned about new findings and progress related to the mRNA vaccine durability research, rational vaccine design, supply and logistics planning, and immune profiling.
xMAP® Technology: Providing Comprehensive Immune Profiling Insights for Vaccine Development
We were also honored to have our own Dominic Andrada provide a presentation during the meeting’s Immune Profiling session. In his talk, titled “Updated Strategies for Immune Profiling in Vaccine Development with xMAP® Technology,” he explained that immune profiling is a popular application for xMAP Technology because its unique multiplexing capacity allows for truly comprehensive and quantitative views of the many components involved in immune response. This is particularly relevant to the vaccine development community, where advances in mRNA vaccines, cancer vaccines, recombinant antigens, and new adjuvants, among other factors, have been driving demand for immune profiling data.
With so many new avenues for vaccine development, it’s important to have a robust, reliable technology for these immune profiling experiments. As the global community moves beyond its three-year focus on COVID-19 vaccines, there will be a strong need to understand cellular immune response in vaccine candidates.
Applications of xMAP Technology in Vaccine Development
For many xMAP users, cytokine measurement in vaccine response is a key area of interest, and this is an especially good fit for our xMAP INTELLIFLEX® System, which has an optional dual-reporter channel to measure closely related analytes. Relevant real-world examples include an analysis of IgG and IgM antibody responses to SARS-CoV-2 antigens and the use of xMAP Technology to develop a cost-effective COVID-19 vaccine, known as Corbevax at Baylor’s Center for Vaccine Development.
Other relevant applications of our multiplexing technology include the identification of secreted proteins, mechanism of action studies, pathogen detection, genotyping, the measurement of protein-protein interactions, and more.