Immunogenicity Profiling of Nanocarriers
For our second Webinar Wednesday blog, we’re featuring a talk from Mahmoud Elsabahy who is working to establish a new immunotoxicity index for multiplex data analysis and interpretation. He uses xMAP® Technology to trace the biomarker response to nanomedicines and nanocarriers. Dr. Elsabahy is the Assistant Director of the Laboratory for Synthetic-Biologic Interactions at Texas A&M University and is an Associate Professor in the Department of Pharmaceutics at Assiut University in Egypt.
His research interests include:
- the rational design of nanomedicine for various biomedical applications, and
- identifying new approaches to profile biomarkers of immunogenicity and immunotoxicity.
In this 30-minute webinar, you’ll learn about a new model currently in development for multiplex data processing and analysis that Dr. Elsabahy uses to support his work of converting traditional therapies into targeted nanomedicines. Topics include:
- Monitoring cytokines to partially predict the in vivo pharmacokinetics of nanoparticles,
- development of an immunotoxicity index, a single descriptive numerical value (like IC50, LD50, or AUC), that will assist researches to optimally understand, use and present multiplex data, and
- demonstrating the usefulness of the immunotoxicity index for evaluating the impact of surface charge, crosslinking and degradability of nanoparticles.
About Webinar Wednesday
In 2018, we are presenting a new blog series called Webinar Wednesday. Throughout this series, we will share the diverse work of the xMAP multiplexing community by highlighting webinars from the xMAP Connect users group meetings, live webinars, Luminex field application scientists, and Luminex partners. We hope you enjoy the new series!
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